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C1galt1tm1.1Rpmc
Targeted Allele Detail
Nomenclature
Symbol: C1galt1tm1.1Rpmc
Name: core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1; targeted mutation 1.1, Rodger P McEver
MGI ID: MGI:3713768
Synonyms: T-synF
Gene: C1galt1  Location: Chr6:7845224-7872042 bp, + strand  Genetic Position: Chr6, 3.37 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:122012
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsES cells containing a loxP site 5' of exon 1 and a floxed neo in intron 2 were transfected with cre recombinase, resulting in the deletion of the neo. (J:122012)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any C1galt1 Mutation:  17 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Premature Ovarian Failure J:125880, J:237228.
References
Original:  J:122012 Williams SA, et al., Fertilization in mouse does not require terminal galactose or N-acetylglucosamine on the zona pellucida glycans. J Cell Sci. 2007 Apr 15;120(Pt 8):1341-9
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
08/13/2019
MGI 6.14
The Jackson Laboratory