About   Help   FAQ
Tg(Aqp2-cre)1Dek
Transgene Detail
Nomenclature
Symbol: Tg(Aqp2-cre)1Dek
Name: transgene insertion 1, Donald E Kohan
MGI ID: MGI:3712435
Synonyms: AQP2-Cre
Transgene: Tg(Aqp2-cre)1Dek  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene contains a 9.5 kb fragment of the mouse aquaporin 2 gene 5'-flanking region placed upstream of a Cre recombinase sequence (with SV40 nuclear localization signal at the amino terminus and an 11-amino acid epitope tag derived from Herpes simplex virus glycoprotein D located at the carboxy terminus). The aquaporin regulatory sequences drive Cre expression in the collecting ducts of the kidney and in sperm. (J:104785)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Aqp2     Summary of all recombinase alleles driven by Aqp2.
 

Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:104785 Ge Y, et al., Collecting duct-specific knockout of endothelin-1 alters vasopressin regulation of urine osmolality. Am J Physiol Renal Physiol. 2005 May;288(5):F912-20
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/17/2015
MGI 5.21
The Jackson Laboratory