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Ightm2Mnz
Targeted Allele Detail
Nomenclature
Symbol: Ightm2Mnz
Name: immunoglobulin heavy chain complex; targeted mutation 2, Michel C Nussenzweig
MGI ID: MGI:3712225
Synonyms: B1-8lo
Gene: Igh  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:75653
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsThe following point mutations were inserted into the VHB1-8 region: GCT to GGT (Ala24Gly), AGC to ACC (Ser31Thr), CAC to CAG (His35Gln), AGA to ACT (Arg98Thr). A floxed neo included in the vector was subsequently removed via cre mediated recombination. (J:75653)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igh Mutation:  36 strains or lines available
References
Original:  J:75653 Shih TA, et al., Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nat Immunol. 2002 Apr;3(4):399-406
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/08/2020
MGI 6.15
The Jackson Laboratory