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Targeted Allele Detail
Symbol: Plod1tm1Soin
Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; targeted mutation 1, Raija Soininen
MGI ID: MGI:3712146
Synonyms: Plod1-
Gene: Plod1  Location: Chr4:147909753-147936767 bp, - strand  Genetic Position: Chr4, 78.57 cM
Gait abnormalities in Plod1tm1Soin/Plod1tm1Soin mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:120891
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe lacZ-neo reporter was fused in-frame to exon 2. Homologous recombination led to the deletion of exons 3-6 and fusion of the endogenous 129 bp 5' sequence into the bacterial beta-gal gene. RT-PCR confirmed absence of transcript in mutant heart. (J:120891)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plod1 Mutation:  6 strains or lines available
Original:  J:120891 Takaluoma K, et al., Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem. 2007 Mar 2;282(9):6588-96
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory