Plod1^{Gt(RST531)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Plod1^{Gt(RST531)Byg}
• Name: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1; gene trap RST531, BayGenomics
• MGI ID: MGI:3712145
• Synonyms: Plod1^-
• Gene: Plod1 Location: Chr4:147994210-148021224 bp, - strand Genetic Position: Chr4, 78.57 cM
• Alliance: Plod1^{Gt(RST531)Byg} page

Mutation origin

• Mutant Cell Line: RST531
• Germline Transmission: Earliest citation of germline transmission: J:120891
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2TMpfs Vector Type: secretory trap
• Mutation details: A gene trap vector containing a betageo was inserted into exon 12. The resulting transcript was of the truncated locus and betageo. (J:120891)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RST531	CC199777 ; (MGI Seq Detail)	5' RACE	Chr4:148005854-148005946 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  4 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Plod1 Mutation: 27 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:120891 Takaluoma K, et al., Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice. J Biol Chem. 2007 Mar 2;282(9):6588-96
• All: 3 reference(s)