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Tsc2tm1.1Mjg
Targeted Allele Detail
Summary
Symbol: Tsc2tm1.1Mjg
Name: TSC complex subunit 2; targeted mutation 1.1, Michael J Gambello
MGI ID: MGI:3712063
Synonyms: Tsc2flox
Gene: Tsc2  Location: Chr17:24814790-24851604 bp, - strand  Genetic Position: Chr17, 12.41 cM
Alliance: Tsc2tm1.1Mjg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121748
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsThis allele contains loxP sites flanking exons 2, 3 and 4. A frt-flanked neomycin selection cassette was removed from the first intron by crossing with mice expressing FLP recombinase in the germline, leaving a single frt site downstream of the first loxP site. (J:121748)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 13 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tsc2tm1.1Mjg
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tsc2 Mutation:  48 strains or lines available
References
Original:  J:121748 Hernandez O, et al., Generation of a conditional disruption of the Tsc2 gene. Genesis. 2007 Feb;45(2):101-6
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory