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Tpmttm1Rlng
Targeted Allele Detail
Nomenclature
Symbol: Tpmttm1Rlng
Name: thiopurine methyltransferase; targeted mutation 1, Mary V Relling
MGI ID: MGI:3712056
Synonyms: Tpmt-
Gene: Tpmt  Location: Chr13:47025170-47044737 bp, - strand  Genetic Position: Chr13, 24.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121737
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Sequence containing exons V and VI was replaced with a neomycin resistance gene. (J:121737)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tpmt Mutation:  11 strains or lines available
References
Original:  J:121737 Hartford C, et al., Differential effects of targeted disruption of thiopurine methyltransferase on mercaptopurine and thioguanine pharmacodynamics. Cancer Res. 2007 May 15;67(10):4965-72
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory