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Targeted Allele Detail
Symbol: Sorbs1tm1Krc
Name: sorbin and SH3 domain containing 1; targeted mutation 1, Kenneth Chien
MGI ID: MGI:3711721
Synonyms: Sorbs1-
Gene: Sorbs1  Location: Chr19:40294753-40513779 bp, - strand  Genetic Position: Chr19, 34.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:121762
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTwo exons that were common to all known variants were replaced by a neomycin resistance cassette, thereby disrupting the reading frame and rendering the gene inactive. Absence of transcript was confirmed in mutant adipose tissue, liver, muscle and heart. (J:121762)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sorbs1 Mutation:  81 strains or lines available
Original:  J:121762 Lesniewski LA, et al., Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance. Nat Med. 2007 Apr;13(4):455-62
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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