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Kdm1atm1.2Rsd
Targeted Allele Detail
Nomenclature
Symbol: Kdm1atm1.2Rsd
Name: lysine (K)-specific demethylase 1A; targeted mutation 1.2, Michael G Rosenfeld
MGI ID: MGI:3711561
Synonyms: Lsd1-
Gene: Kdm1a  Location: Chr4:136550540-136602723 bp, - strand  Genetic Position: Chr4, 68.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121427
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was used to insert loxP sites to flank an HSVTK-PGKNeo cassette and exon 6, which corresponds to the amino terminus of the amine oxidase domain. A type I recombination event in ES cells resulted in deletion of the selection cassette and exon6, leaving a single loxP site. (J:121427)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kdm1a Mutation:  30 strains or lines available
References
Original:  J:121427 Wang J, et al., Opposing LSD1 complexes function in developmental gene activation and repression programmes. Nature. 2007 Apr 19;446(7138):882-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/17/2017
MGI 6.10
The Jackson Laboratory