Rdh9^tm1Jln
Targeted Allele Detail

Summary

• Symbol: Rdh9^tm1Jln
• Name: retinol dehydrogenase 9; targeted mutation 1, Joseph L Napoli
• MGI ID: MGI:3711415
• Synonyms: Rdh9^-
• Gene: Rdh9 Location: Chr10:127612274-127628566 bp, + strand Genetic Position: Chr10, 75.21 cM
• Alliance: Rdh9^tm1Jln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121381
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was flanked by loxP sites. Transient expression of cre recombinase removed the floxed sequence. RT-PCR confirmed absence of transcript in mutant liver. (J:121381)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rdh9 Mutation: 14 strains or lines available

References

• Original: J:121381 Hu P, et al., Ontogeny of rdh9 (Crad3) expression: ablation causes changes in retinoid and steroid metabolizing enzymes, but RXR and androgen signaling seem normal. Biochim Biophys Acta. 2007 Apr;1770(4):694-705
• All: 1 reference(s)