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Cmahtm1Ykoz
Targeted Allele Detail
Nomenclature
Symbol: Cmahtm1Ykoz
Name: cytidine monophospho-N-acetylneuraminic acid hydroxylase; targeted mutation 1, Yasunori Kozutsumi
MGI ID: MGI:3711330
Synonyms: Cmah-
Gene: Cmah  Location: Chr13:24511387-24661272 bp, + strand  Genetic Position: Chr13, 10.34 cM, cytoband A3.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121365
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a neo into the second coding exon. Western blot failed to detect protein in mutants. (J:121365)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cmah Mutation:  25 strains or lines available
References
Original:  J:121365 Naito Y, et al., Germinal center marker GL7 probes activation-dependent repression of N-glycolylneuraminic acid, a sialic acid species involved in the negative modulation of B-cell activation. Mol Cell Biol. 2007 Apr;27(8):3008-22
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/26/2022
MGI 6.21
The Jackson Laboratory