Hey2^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Hey2^tm1Eno
• Name: hairy/enhancer-of-split related with YRPW motif 2; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3711158
• Synonyms: Hrt2^loxP
• Gene: Hey2 Location: Chr10:30708355-30718779 bp, - strand Genetic Position: Chr10, 17.19 cM, cytoband A4
• Alliance: Hey2^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:121577
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were introduced to flank exons 1-3. A neo included in the vector was removed by flp mediated recombination. (J:121577)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hey2 Mutation: 30 strains or lines available

References

• Original: J:121577 Xin M, et al., Essential roles of the bHLH transcription factor Hrt2 in repression of atrial gene expression and maintenance of postnatal cardiac function. Proc Natl Acad Sci U S A. 2007 May 8;104(19):7975-80
• All: 6 reference(s)