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Dmrtc2tm1.2Zark
Targeted Allele Detail
Nomenclature
Symbol: Dmrtc2tm1.2Zark
Name: doublesex and mab-3 related transcription factor like family C2; targeted mutation 1.2, David Zarkower
MGI ID: MGI:3711104
Synonyms: Dmrt7-
Gene: Dmrtc2  Location: Chr7:24870057-24877651 bp, + strand  Genetic Position: Chr7, 13.33 cM, cytoband A3
Germ cell apoptosis in Dmrtc2tm1.2Zark/Dmrtc2tm1.2Zark mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:121537
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCrossing Dmrtc2tm1Zark mice with mice expressing cre in the germline resulted in the deletion of exons 2 and 3, as well as the frt-flanked neo. (J:121537)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dmrtc2 Mutation:  11 strains or lines available
References
Original:  J:121537 Kim S, et al., A mammal-specific Doublesex homolog associates with male sex chromatin and is required for male meiosis. PLoS Genet. 2007 Apr 20;3(4):e62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory