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Targeted Allele Detail
Symbol: Abca3tm1Nina
Name: ATP-binding cassette, sub-family A (ABC1), member 3; targeted mutation 1, Nobuya Inagaki
MGI ID: MGI:3709991
Synonyms: Abca3-
Gene: Abca3  Location: Chr17:24351950-24410201 bp, + strand  Genetic Position: Chr17, 12.38 cM, cytoband A3.3
Lung abnormalities in Abca3tm1Nina/Abca3tm1Nina mice, including pulmonary congestion and atelectasis

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:121155
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA pgk-neo cassette was inserted to replace a 2948-bp fragment containing the four exons encoding the first nucleotide-binding domain. Absence of protein was confirmed by immunoblot of mutant lung tissue. (J:121155)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abca3 Mutation:  5 strains or lines available
Original:  J:121155 Ban N, et al., ABCA3 as a lipid transporter in pulmonary surfactant biogenesis. J Biol Chem. 2007 Mar 30;282(13):9628-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory