Tg(CD19-BTK)1Rwhe
Transgene Detail

Summary

• Symbol: Tg(CD19-BTK)1Rwhe
• Name: transgene insertion 1, Rudolf Hendriks
• MGI ID: MGI:3709187
• Synonyms: CD19-hBtk
• Transgene: Tg(CD19-BTK)1Rwhe Location: unknown
• Alliance: Tg(CD19-BTK)1Rwhe page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD19-BTK)1Rwhe expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  BTK (695)

  Btk	(MGI:88216)

• Mutation details: A composite fragment composed of 400bp from exons 1-3 of a BTK cDNA as well as 27kb genomic fragment containing exons 3-19 of BTK was placed under the control of the promoter region of human CD19. (J:120990)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:120990 Maas A, et al., Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region. J Immunol. 1999 Jun 1;162(11):6526-33
• All: 7 reference(s)