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Adamts13tm2Dgi
Targeted Allele Detail
Nomenclature
Symbol: Adamts13tm2Dgi
Name: a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 13; targeted mutation 2, David Ginsburg
MGI ID: MGI:3708852
Synonyms: Adamts13conditional, Adamts13/delta Neo
Gene: Adamts13  Location: Chr2:26973416-27009628 bp, + strand  Genetic Position: Chr2, 19.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:101752
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 of Adamts13 was flanked with LoxP sequences (plus an additonal LoxP located 511 bp 3'). In addition, a floxed neomycin cassette was inserted between exons 2 and 3. (J:101752)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adamts13 Mutation:  45 strains or lines available
References
Original:  J:101752 Motto DG, et al., Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest. 2005 Oct;115(10):2752-61
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory