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Cubntm1Sarg
Targeted Allele Detail
Summary
Symbol: Cubntm1Sarg
Name: cubilin; targeted mutation 1, Scott Argraves
MGI ID: MGI:3707335
Synonyms: Cubndelexon1-6;EGFP
Gene: Cubn  Location: Chr2:13281149-13496624 bp, - strand  Genetic Position: Chr2, 9.86 cM
Alliance: Cubntm1Sarg page
Cubntm1Sarg/Cubntm1Sarg embryos display growth retardation at 8-8.5dpc

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119685
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe promoter-less EGFP and floxed neo cassette were inserted into exon 1, 33 bp upstream of the ATG and 16 bp downstream from the proximal transcription initiation site. Homologous recombination resulted in the loss of most of exon 1 and all of exons 2-6. (J:119685)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 6 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cubn Mutation:  160 strains or lines available
References
Original:  J:119685 Smith BT, et al., Targeted disruption of cubilin reveals essential developmental roles in the structure and function of endoderm and in somite formation. BMC Dev Biol. 2006;6:30
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory