Ndor1Tg(UBC-cre/ERT2)1Ejb
Transgenic Allele Detail
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Symbol: |
Ndor1Tg(UBC-cre/ERT2)1Ejb |
Name: |
NADPH dependent diflavin oxidoreductase 1; transgene insertion 1, Eric J Brown |
MGI ID: |
MGI:3707333 |
Synonyms: |
Cre-ER, Cre-ERT2, CreT2, hUBC-CreERT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ERT2)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, UBC-Cre-ER-LBD-tg, Ubc-cre/ERT2, UBC-CreERt2, UBC-CreERT2, UBC-CreERT2 |
Gene: |
Ndor1 Location: Chr2:25134825-25145458 bp, - strand Genetic Position: Chr2, 17.1 cM
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Alliance: |
Ndor1Tg(UBC-cre/ERT2)1Ejb page
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Strain of Origin: |
(129S/SvEv x C57BL/6)
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Transgene Type: |
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Transgenic (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutations: |
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Insertion, Intragenic deletion
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Ndor1Tg(UBC-cre/ERT2)1Ejb expression driven by
1 gene
Transgene expression driven by:
Organism |
Driver Gene |
Homolog in Mouse |
Note |
human |
UBC (7316) |
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Mutation details: This Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types. Line 1 inserted into the gene at 25249816-25249821 (Build GRCm38/mm10) resulting in a 5 bp deletion.
(J:123200)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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UBC
(human)
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:123200 Ruzankina Y, et al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007 Jun 7;1(1):113-26 |
All: |
485 reference(s) |
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