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Transgenic Allele Detail
Symbol: Ndor1Tg(UBC-cre/ERT2)1Ejb
Name: NADPH dependent diflavin oxidoreductase 1; transgene insertion 1, Eric J Brown
MGI ID: MGI:3707333
Synonyms: Cre-ER, Cre-ERT2, CreT2, hUBC-CreERT2, Tg(UBC-cre)1Ejb, Tg(UBC-cre/ERT2)1Ejb, Tg(UBC-cre/ESR1)1Ejb, Ubc-cre, Ubc-creER, UBC-Cre-ER-LBD-tg, Ubc-cre/ERT2, UBC-CreERt2, UBC-CreERT2
Gene: Ndor1  Location: Chr2:25134825-25145458 bp, - strand  Genetic Position: Chr2, 17.1 cM
Strain of Origin:  (129S/SvEv x C57BL/6)
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
Mutation detailsThis Cre-ERT2 transgenic mouse line was generated via lentitransgenesis; a self-inactivating lentiviral vector was designed with the human ubiquitin C (UBC) promoter sequence upstream of a Cre-ERT2 fusion gene (Cre recombinase fused to a G400V/M543A/L544A triple mutation of the human estrogen receptor ligand binding domain). Cre-ERT2-expressing lentivirus were microinjected into the perivitelline space of one-cell zygotes (129SvEv;C57BL/6 mixed genetic background). Mice display tamoxifen-inducible Cre activity in all tissue types. Line 1 inserted into the gene at 25249816-25249821 (Build GRCm38/mm10) resulting in a 5 bp deletion. (J:123200)
 Tissue activity of this recombinase allele
Driver: UBC     Summary of all recombinase alleles driven by UBC.

View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ndor1 Mutation:  23 strains or lines available
Original:  J:123200 Ruzankina Y, et al., Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell. 2007 Jun 7;1(1):113-26
All:  343 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory