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Sumf1Gt(RST760)Byg
Gene trapped Allele Detail
Nomenclature
Symbol: Sumf1Gt(RST760)Byg
Name: sulfatase modifying factor 1; gene trap RST760, BayGenomics
MGI ID: MGI:3707232
Synonyms: Sumf1-
Gene: Sumf1  Location: Chr6:108083989-108162543 bp, - strand  Genetic Position: Chr6, 49.71 cM
Appearance of Sumf1Gt(RST760)Byg/Sumf1Gt(RST760)Byg mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Mutant Cell Line:  RST760
Germline Transmission:  Earliest citation of germline transmission: J:120146
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Gene trapped (Null/knockout, Reporter)
Mutation:    Insertion of gene trap vector     Vector: pGT0TMpfs     Vector Type: secretory trap
 
Mutation detailsA gene trap vector was inserted into intron 3. RT-PCR demonstrated that the fusion transcript was composed by the first three exons of the locus and beta-geo. (J:120146)
Sequence Tags: 
Sequence tag details (1 tag)
Genome Context: 
Genome Browser view of this mutation
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 27 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sumf1 Mutation:  26 strains or lines available
Notes
All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.
ES cells used are CGR8 or E14TG2
References
Original:  J:120146 Settembre C, et al., Systemic inflammation and neurodegeneration in a mouse model of multiple sulfatase deficiency. Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4506-11
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory