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Cdh8tm1Mta
Targeted Allele Detail
Nomenclature
Symbol: Cdh8tm1Mta
Name: cadherin 8; targeted mutation 1, Masatoshi Takeichi
MGI ID: MGI:3707077
Synonyms: Cad8-, Cdh8LacZ
Gene: Cdh8  Location: Chr8:99024471-99416471 bp, - strand  Genetic Position: Chr8, 49.4 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120130
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe sequences encoding the first 83 amino acids were replaced by a taulacZ or gaplacZ and floxed neo cassette into exon 2. The floxed neo was removed via cre mediated recombination. Western blot confirmed absence of protein in mutant spinal cord. (J:120130)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 38 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdh8 Mutation:  2 strains or lines available
References
Original:  J:120130 Suzuki SC, et al., Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation. J Neurosci. 2007 Mar 28;27(13):3466-76
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory