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Cyp26c1tm1.1Keya
Targeted Allele Detail
Nomenclature
Symbol: Cyp26c1tm1.1Keya
Name: cytochrome P450, family 26, subfamily c, polypeptide 1; targeted mutation 1.1, Kenta Yashiro
MGI ID: MGI:3706550
Gene: Cyp26c1  Location: Chr19:37685680-37693307 bp, + strand  Genetic Position: Chr19, 32.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119939
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA selection cassette containing a loxP site and frt flanked neomycin gene was inserted in intron 5. A second loxP site was inserted into the 3' untranslated region as well. Exon 6 was then deleted by cre-mediated excision of a floxed neo cassette. Excision was confirmed by PCR of genomic DNA. (J:119939)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp26c1 Mutation:  12 strains or lines available
References
Original:  J:119939 Uehara M, et al., CYP26A1 and CYP26C1 cooperatively regulate anterior-posterior patterning of the developing brain and the production of migratory cranial neural crest cells in the mouse. Dev Biol. 2007 Feb 15;302(2):399-411
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory