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March1tm1.1Sish
Targeted Allele Detail
Nomenclature
Symbol: March1tm1.1Sish
Name: membrane-associated ring finger (C3HC4) 1; targeted mutation 1.1, Satoshi Ishido
MGI ID: MGI:3706321
Synonyms: March-1-KO
Gene: March1  Location: Chr8:65617922-66471637 bp, + strand  Genetic Position: Chr8, 33.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119918
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 6, encoding the RINGv domain, was flanked by loxP sites and subsequently removed via cre-mediated recombination. Western blot confirmed absence of protein in mutants. (J:119918)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any March1 Mutation:  5 strains or lines available
References
Original:  J:119918 Matsuki Y, et al., Novel regulation of MHC class II function in B cells. EMBO J. 2007 Feb 7;26(3):846-54
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory