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Dlg3tm1Grnt
Targeted Allele Detail
Nomenclature
Symbol: Dlg3tm1Grnt
Name: discs large MAGUK scaffold protein 3; targeted mutation 1, Seth G N Grant
MGI ID: MGI:3706312
Synonyms: SAP102-
Gene: Dlg3  Location: ChrX:100767722-100818410 bp, + strand  Genetic Position: ChrX, 43.72 cM, cytoband C2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120078
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-8 were replaced with a neomycin resistance cassette flanked by loxP sites. Integration of the targeting vector caused a frame shift. Absence of protein was confirmed by Western blot and immunohistochemistry. (J:120078)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dlg3 Mutation:  25 strains or lines available
References
Original:  J:120078 Cuthbert PC, et al., Synapse-associated protein 102/dlgh3 couples the NMDA receptor to specific plasticity pathways and learning strategies. J Neurosci. 2007 Mar 7;27(10):2673-82
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory