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Transgene Detail
Symbol: Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Name: transgene insertion A6, Corinne G Lobe
MGI ID: MGI:3703164
Synonyms: iZ/EG-TEL-AML1, Tg(ACTB-Bgeo,-TEL/AML1,-EGFP)A6Lbe, Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe
Transgene: Tg(CAG-Bgeo,-TEL/AML1,-EGFP)A6Lbe  Location: unknown  
Germline Transmission:  Earliest citation of germline transmission: J:119130
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Transgene Type:    Transgenic (Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Mutation detailsA transgenic construct was designed with the CMV enhancer/chicken beta-actin promoter, loxP-flanked STOP sequence (beta-geo reporter followed by SV40 polyadenylation signal), human TEL-AML1 fusion protein sequence (coding for the translocation t(12;21)(p13;q22)), internal ribosomal entry site, and an enhanced green fluorescent protein (EGFP) gene. Prior to Cre-mediated excision of the "floxed" STOP sequence, high expression of lacZ is observed in cells and tissues. When bred to Cre recombinase expressing mice, the STOP sequence (and beta-geo) is removed in the resulting offspring, allowing transcription/co-expression of both the human TEL-AML1 fusion protein and EGFP to proceed in the Cre recombinase expressing cells. (J:119130)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:119130 Yang W, et al., TEL-AML1 transgene expression in hematopoietic cells produces lymphoblastic leukemia in mice. MGI Direct Data Submission. 2007;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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