Fstl3^tm2Alsc
Targeted Allele Detail

Summary

• Symbol: Fstl3^tm2Alsc
• Name: follistatin-like 3; targeted mutation 2, Alan L Schneyer
• MGI ID: MGI:3702860
• Gene: Fstl3 Location: Chr10:79613108-79618464 bp, + strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Fstl3^tm2Alsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:119526
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neomycin selection cassette was inserted 5' to exon 1 and a third loxP site was inserted in intron 1. This is the same targeting event that created Fstl3^tm1Alsc. Subsequent mating to mice carrying a cre expressing transgene resulted in excision of the neo selection cassette leaving loxP sites on either side of exon 1. (J:119526)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fstl3 Mutation: 22 strains or lines available

References

• Original: J:119526 Mukherjee A, et al., FSTL3 deletion reveals roles for TGF-beta family ligands in glucose and fat homeostasis in adults. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1348-53
• All: 2 reference(s)