Procr^tm2Cte
Targeted Allele Detail

Summary

• Symbol: Procr^tm2Cte
• Name: protein C receptor, endothelial; targeted mutation 2, Charles T Esmon
• MGI ID: MGI:3702857
• Synonyms: EPCR^flox, Procr^Lox
• Gene: Procr Location: Chr2:155593037-155597391 bp, + strand Genetic Position: Chr2, 77.26 cM, cytoband H1-3
• Alliance: Procr^tm2Cte page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:80043
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: This allele is the parent allele of Procr^tm1Cte, whereby exon 1 was flanked by loxP sites with a neomycin resistance cassette and a third loxP site in intron 2. (J:80043)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Procr Mutation: 15 strains or lines available

Notes

ES cell line = AB2.

References

• Original: J:80043 Gu JM, et al., Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality. J Biol Chem. 2002 Nov 8;277(45):43335-43
• All: 8 reference(s)