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Cybrd1tm1Nca
Targeted Allele Detail
Nomenclature
Symbol: Cybrd1tm1Nca
Name: cytochrome b reductase 1; targeted mutation 1, Nancy C Andrews
MGI ID: MGI:3702743
Synonyms: Cybrd1-
Gene: Cybrd1  Location: Chr2:71117923-71142926 bp, + strand  Genetic Position: Chr2, 42.38 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119528
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was designed to insert a loxP site into intron 1 and a loxP-flanked neo/cytosine deaminase cassette into intron 2. Transient expression of cre recombinase resulted in the removal of exon 2. Immunoblot confirmed absence of protein in mutant duodenal lysates. (J:119528)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cybrd1 Mutation:  8 strains or lines available
References
Original:  J:119528 Gunshin H, et al., Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood. 2005 Oct 15;106(8):2879-83
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory