Arvcf^tm1Ais
Targeted Allele Detail

Summary

• Symbol: Arvcf^tm1Ais
• Name: armadillo repeat gene deleted in velocardiofacial syndrome; targeted mutation 1, Arthur I Skoultchi
• MGI ID: MGI:3702625
• Gene: Arvcf Location: Chr16:18166046-18225826 bp, + strand Genetic Position: Chr16, 11.37 cM
• Alliance: Arvcf^tm1Ais page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64380
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing two regions of the armadillo repeat gene deleted in velo-cardio-facial syndrome flanking a hygromycin resistance gene, a loxP site and a promoterless puromycin resistance gene was inserted into the locus. The insertion of this vector resulted in the loss of amino acids 83-276. (J:64380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arvcf Mutation: 82 strains or lines available

References

• Original: J:64380 Puech A, et al., Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10090-5
• All: 1 reference(s)