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Tcrbtm2Slek
Targeted Allele Detail
Nomenclature
Symbol: Tcrbtm2Slek
Name: T cell receptor beta chain; targeted mutation 2, Barry P Sleckman
MGI ID: MGI:3702574
Synonyms: Jbeta1M4
Gene: Tcrb  Location: unknown  Genetic Position: Chr6, cytoband A-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119552
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsES cells containing Tcrbtm1Slek, which contain a loxP site in place of the Dbeta2-Jbeta2 gene cluster, were additionally targeted to replace the 5' Dbeta1 12-RSS with the Jbeta1.2 12-RSS. The allele also contains loxP and HindIII sites between Dbeta1 and Jbeta1.1, as well as the conversion of a bamHI site 3' of Jbeta1.2 to a PstI site. A floxed neo cassette was removed from the locus. (J:119552)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:  77 strains or lines available
References
Original:  J:119552 Bassing CH, et al., Recombination signal sequences restrict chromosomal V(D)J recombination beyond the 12/23 rule. Nature. 2000 Jun 1;405(6786):583-6
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory