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Targeted Allele Detail
Symbol: Lhx6tm2Vpa
Name: LIM homeobox protein 6; targeted mutation 2, Vassilis Pachnis
MGI ID: MGI:3702518
Synonyms: Lhx6-, Lhx6tm2Pach
Gene: Lhx6  Location: Chr2:36081953-36105408 bp, - strand  Genetic Position: Chr2, 24.17 cM
Germline Transmission:  Earliest citation of germline transmission: J:119476
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 through 4 and part of exon 5 were replaced with an IRES-eGFP and a floxed PGK-neo cassette. The neo cassette was then removed in vivo by Cre-mediated recombination. Immunohistochemistry and western blot analysis confirmed near total loss of protein expression in homozygous mice. No GFP expression is seen in heterozygotes. (J:119476)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lhx6 Mutation:  18 strains or lines available
Original:  J:119476 Liodis P, et al., Lhx6 activity is required for the normal migration and specification of cortical interneuron subtypes. J Neurosci. 2007 Mar 21;27(12):3078-89
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory