About   Help   FAQ
Pdx1tm4Cvw
Targeted Allele Detail
Nomenclature
Symbol: Pdx1tm4Cvw
Name: pancreatic and duodenal homeobox 1; targeted mutation 4, Christopher V Wright
MGI ID: MGI:3702084
Synonyms: Ipf1tm3Cvw, Pdx1flE2, Pdx1tm4(E2)Cvw
Gene: Pdx1  Location: Chr5:147269959-147278008 bp, + strand  Genetic Position: Chr5, 86.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130389
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene. (J:130389)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  14 strains or lines available
References
Original:  J:130389 Gannon M, et al., pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol. 2008 Feb 15;314(2):406-17
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory