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Pdx1tm4Cvw
Targeted Allele Detail
Nomenclature
Symbol: Pdx1tm4Cvw
Name: pancreatic and duodenal homeobox 1; targeted mutation 4, Christopher VE Wright
MGI ID: MGI:3702084
Synonyms: Ipf1tm3Cvw, Pdx1flE2, Pdx1tm4(E2)Cvw
Gene: Pdx1  Location: Chr5:147269959-147275848 bp, + strand  Genetic Position: Chr5, 86.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:130389
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
    LoxP sites for Cre recombinase were inserted to flank exon 2 of the gene. (J:130389)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  19 strains or lines available
References
Original:  J:130389 Gannon M, et al., pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis. Dev Biol. 2008 Feb 15;314(2):406-17
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory