About   Help   FAQ
Tg(Cd4-CD4)2362Litt
Transgene Detail
Nomenclature
Symbol: Tg(Cd4-CD4)2362Litt
Name: transgene insertion 2362, Dan R Littman
MGI ID: MGI:3702083
Transgene: Tg(Cd4-CD4)2362Litt  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Cd4-CD4)2362Litt expresses 1 gene
 
Mutation detailsA 4.5 kb BglII-EcoRI fragment encompassing a T cell-specific enhancer element located 13 kb upstream of the transcription initiation site in the murine CD4 gene was ligated to a 30 kb human CD4 minigene that includes the promoter and all of the human protein coding region. Line 2362 carries approximately six copies of this transgenic construct and expresses a level of CD4 equivalent to that seen on human peripheral CD4+ T cells. Transgenic mice do not express human CD4 on their peripheral CD8+ T cells, consistent with appropriate cis-acting transcriptional silencing of the human CD4 transgene from the T cell-specific enhancer element. (J:50435)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:50435 Killeen N, et al., Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 1993 Apr;12(4):1547-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory