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Transgene Detail
Symbol: Tg(Cd4-CD4)2362Litt
Name: transgene insertion 2362, Dan R Littman
MGI ID: MGI:3702083
Transgene: Tg(Cd4-CD4)2362Litt  Location: unknown  
Strain of Origin:  (C57BL/6 x SJL)F2
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(Cd4-CD4)2362Litt expresses 1 gene
Mutation detailsA 4.5 kb BglII-EcoRI fragment encompassing a T cell-specific enhancer element located 13 kb upstream of the transcription initiation site in the murine CD4 gene was ligated to a 30 kb human CD4 minigene that includes the promoter and all of the human protein coding region. Line 2362 carries approximately six copies of this transgenic construct and expresses a level of CD4 equivalent to that seen on human peripheral CD4+ T cells. Transgenic mice do not express human CD4 on their peripheral CD8+ T cells, consistent with appropriate cis-acting transcriptional silencing of the human CD4 transgene from the T cell-specific enhancer element. (J:50435)
View phenotypes and curated references for all genotypes (concatenated display).
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Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Original:  J:50435 Killeen N, et al., Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. EMBO J. 1993 Apr;12(4):1547-53
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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