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Rev1tm1Ndew
Targeted Allele Detail
Nomenclature
Symbol: Rev1tm1Ndew
Name: REV1, DNA directed polymerase; targeted mutation 1, Niels de Wind
MGI ID: MGI:3701945
Gene: Rev1  Location: Chr1:38052786-38129801 bp, - strand  Genetic Position: Chr1, 16.46 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:119176
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 10 was replaced with a PGK-hygro cassette to create a null allele. A western blot using alpha-Rev1 antiserum confirmed the absence of protein in MEF lysates. An RT-PCR of kidney cDNA established the absence of exon 10 in expressed transcripts. (J:119176)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rev1 Mutation:  43 strains or lines available
References
Original:  J:119176 Jansen JG, et al., Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice. J Exp Med. 2006 Feb 20;203(2):319-23
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/11/2017
MGI 6.10
The Jackson Laboratory