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Targeted Allele Detail
Symbol: Apobec3tm1Msn
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; targeted mutation 1, Michael S Neuberger
MGI ID: MGI:3701836
Gene: Apobec3  Location: Chr15:79891659-79915906 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E2
Germline Transmission:  Earliest citation of germline transmission: J:119326
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neo cassette was inserted into exon 3 resulting in a null allele. Targeted mutation was confirmed by northern and western blot that showed no RNA or protein expression, respectively, in spleen tissue. (J:119326)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apobec3 Mutation:  114 strains or lines available
Original:  J:119326 Mikl MC, et al., Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol. 2005 Aug;25(16):7270-7
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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