Gnl3^{Gt(W223E05)Wrst}
Gene trapped Allele Detail

Summary

• Symbol: Gnl3^{Gt(W223E05)Wrst}
• Name: guanine nucleotide binding protein nucleolar 3; gene trap W223E05, Wolfgang Wurst
• MGI ID: MGI:3701318
• Synonyms: NS^-
• Gene: Gnl3 Location: Chr14:30734390-30741088 bp, - strand Genetic Position: Chr14, 19.09 cM
• Alliance: Gnl3^{Gt(W223E05)Wrst} page

Mutation origin

• Mutant Cell Line: W223E05
• Germline Transmission: Earliest citation of germline transmission: J:118144
• Parent Cell Line: TBV2 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: ROSAbetageo
• Mutation details: A gene trap vector containing a Betageo, a splice acceptor site and a transcriptional stop element integrated into intron 1. The mutant allele was expected to drive the expression of a fusion protein encoding the first four amino acids of the endogenous gene and the betageo reporter. (J:118144)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  W223E05	CL215544 ; (MGI Seq Detail)	5' RACE	Chr14:30740885-30741006 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  163 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gnl3 Mutation: 58 strains or lines available

References

• Original: J:118144 Beekman C, et al., Evolutionarily conserved role of nucleostemin: controlling proliferation of stem/progenitor cells during early vertebrate development. Mol Cell Biol. 2006 Dec;26(24):9291-301
• All: 3 reference(s)