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Targeted Allele Detail
Symbol: Trp53inp1tm1Acar
Name: transformation related protein 53 inducible nuclear protein 1; targeted mutation 1, Alice Carrier
MGI ID: MGI:3700974
Synonyms: inp1-, Trnp53-
Gene: Trp53inp1  Location: Chr4:11156431-11174379 bp, + strand  Genetic Position: Chr4, 5.03 cM, cytoband A1-A2
Germline Transmission:  Earliest citation of germline transmission: J:118867
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2-4 were replaced with a floxed neomycin resistance cassette. The neo was subsequently removed as the targeting vector also contained a cre recombinase gene under the control of the testes-specific angiotensin-converting enzyme gene promoter. RT-PCR confirmed absence of transcript in mutant spleens. (J:118867)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trp53inp1 Mutation:  16 strains or lines available
Original:  J:118867 Gommeaux J, et al., Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol. 2007 Mar;27(6):2215-28
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.11
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