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Trp53inp1tm1Acar
Targeted Allele Detail
Nomenclature
Symbol: Trp53inp1tm1Acar
Name: transformation related protein 53 inducible nuclear protein 1; targeted mutation 1, Alice Carrier
MGI ID: MGI:3700974
Synonyms: inp1-, Trnp53-
Gene: Trp53inp1  Location: Chr4:11156431-11174379 bp, + strand  Genetic Position: Chr4, 5.03 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118867
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2-4 were replaced with a floxed neomycin resistance cassette. The neo was subsequently removed as the targeting vector also contained a cre recombinase gene under the control of the testes-specific angiotensin-converting enzyme gene promoter. RT-PCR confirmed absence of transcript in mutant spleens. (J:118867)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Trp53inp1 Mutation:  12 strains or lines available
References
Original:  J:118867 Gommeaux J, et al., Colitis and colitis-associated cancer are exacerbated in mice deficient for tumor protein 53-induced nuclear protein 1. Mol Cell Biol. 2007 Mar;27(6):2215-28
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory