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Transgene Detail
Symbol: Tg(TERT)C10Hode
Name: transgene insertion C10, Richard J Hodes
MGI ID: MGI:3700152
Synonyms: BAC-C10, hTERT, hTERT-BAC-C10, line BAC-C10
Transgene: Tg(TERT)C10Hode  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(TERT)C10Hode expresses 1 gene
Mutation detailsA linearized bacterial artificial chromosome (BAC) containing the 54-kb human telomerase reverse transcriptase gene, including at least 11 kb of upstream sequence, all of the exons and introns, and 1.2 kb of downstream sequence, was microinjected into C57BL/6 oocytes. Transcript expression patterns of the human gene in most organs of transgenic mice are generally characteristic of TERT expression in humans, rather than of the endogenous mouse gene; the exception is that human TERT, which is not expressed in human brain, is like the mouse enzyme expressed in mouse brain. (J:117922)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Mice of two independent transgenic founder lines, designated BAC-C2 and BAC-C10, were crossed with mice heterozygous for a targeted mutation of the endogenous mouse Tert gene to produce lines segregating for the transgene and the targeted mutation. Expression analyses were performed on mice of various genotypes from both lines. Most data presented were from line BAC-C10.
Original:  J:117922 Horikawa I, et al., Differential cis-regulation of human versus mouse TERT gene expression in vivo: identification of a human-specific repressive element. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18437-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory