St6gal1^tm2Jxm
Targeted Allele Detail

Summary

• Symbol: St6gal1^tm2Jxm
• Name: beta galactoside alpha 2,6 sialyltransferase 1; targeted mutation 2, Jamey Marth
• MGI ID: MGI:3699718
• Synonyms: ST6Gal^F
• Gene: St6gal1 Location: Chr16:23043490-23179100 bp, + strand Genetic Position: Chr16, 14.03 cM
• Alliance: St6gal1^tm2Jxm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79166
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette upstream of exon 2 and a lox P site downstream of the exon. ES cells were transfected with a Cre expression plasmid to excise the neo cassette, leaving the floxed exon. (J:79166)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any St6gal1 Mutation: 55 strains or lines available

References

• Original: J:79166 Hennet T, et al., Immune regulation by the ST6Gal sialyltransferase. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4504-9
• All: 3 reference(s)