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Mgat4btm1Jxm
Targeted Allele Detail
Nomenclature
Symbol: Mgat4btm1Jxm
Name: mannoside acetylglucosaminyltransferase 4, isoenzyme B; targeted mutation 1, Jamey Marth
MGI ID: MGI:3699595
Synonyms: Mgat4bF, Mgat4b type II
Gene: Mgat4b  Location: Chr11:50225335-50235103 bp, + strand  Genetic Position: Chr11, 30.37 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:212313
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was used to place a floxed neomycin-thymidine kinase expression cassette downstream of exons 2, 3, and 4, and a loxP site upstream of the exons. The construct was electroporated into (129X1/SvJ x 129S1/Sv)F1-Kitl+-derived R1 embryonic stem (ES) cells. Correctly targeted ES cells were transfected with Cre expression plasmid to excise the neo fragment and leave the floxed exons. (J:101977, J:212313)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mgat4b Mutation:  22 strains or lines available
References
Original:  J:212313 Takamatsu S, et al., Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice. Glycobiology. 2010 Jan;20(4):485-97
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/10/2019
MGI 6.14
The Jackson Laboratory