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Targeted Allele Detail
Symbol: Syt7tm2Sud
Name: synaptotagmin VII; targeted mutation 2, Thomas C Sudhof
MGI ID: MGI:3699592
Synonyms: C2B KI/KO
Gene: Syt7  Location: Chr19:10366454-10430544 bp, + strand  Genetic Position: Chr19, 6.58 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:118319
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA targeting vector containing point mutations D303A, D357A, and D359A in exon 13 as well as a floxed neomycin gene in intron 12 was electroporated into (129X1/SvJ x 129S1/Sv)F1-Kitl+-derived R1 embryonic stem (ES) cells. The neomycin gene was removed by crossing with a Cre deleter strain, which left the expression level at 20-30% of wild-type. (J:118319, J:131423)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt7 Mutation:  30 strains or lines available
Original:  J:118319 Sudhof TC, A modified knock-in mutation of Syt7. MGI Direct Data Submission. 2007;
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory