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Spry4tm1Ayos
Targeted Allele Detail
Nomenclature
Symbol: Spry4tm1Ayos
Name: sprouty RTK signaling antagonist 4; targeted mutation 1, Akihiko Yoshimura
MGI ID: MGI:3699499
Gene: Spry4  Location: Chr18:38586268-38601268 bp, - strand  Genetic Position: Chr18, 20.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:116506
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a neomycin resistance cassette. Western blot confirmed absence of protein in mutants. (J:116506)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Spry4 Mutation:  37 strains or lines available
References
Original:  J:116506 Taniguchi K, et al., Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling. Biochem Biophys Res Commun. 2007 Jan 26;352(4):896-902
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory