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Foxp3tm2Tch
Targeted Allele Detail
Nomenclature
Symbol: Foxp3tm2Tch
Name: forkhead box P3; targeted mutation 2, Talal A Chatila
MGI ID: MGI:3699400
Synonyms: Foxp3EGFP, FoxP3.GFP, Foxp3-GFP KI, Foxp3IRES-GFP, Foxp3tm2(EGFP)Tch
Gene: Foxp3  Location: ChrX:7445915-7461482 bp, + strand  Genetic Position: ChrX, 3.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:120713
Parent Cell Line:  SCC10 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-EGFP-SV40 poly A sequence was inserted immediately downstream of the endogenous Foxp3 translational stop codon, but upstream of the endogenous polyA signal, generating a bicistronic locus encoding both Foxp3 and EGFP. Expression of EGFP is restricted to the T cell lineage, primarily to the CD4+ T cell population. (J:120713)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  52 strains or lines available
References
Original:  J:120713 Haribhai D, et al., Regulatory T cells dynamically control the primary immune response to foreign antigen. J Immunol. 2007 Mar 1;178(5):2961-72
All:  167 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory