About   Help   FAQ
Trp53tm5Wahl
Targeted Allele Detail
Summary
Symbol: Trp53tm5Wahl
Name: transformation related protein 53; targeted mutation 5, Geoffrey M Wahl
MGI ID: MGI:3699248
Synonyms: P53TTAA
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm5Wahl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118244
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Nucleotide substitutions
 
Mutation detailsThreonine codons 76 (ACC) and 86 (ACT) were changed to alanine (GCC, GCT) (p.T76A, p.T86A). The loxP site flanked neomycin resistance gene cassette that was inserted into intron 6 was removed through subsequent Cre-mediated recombination. (J:118244)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:118244 Toledo F, et al., Mouse mutants reveal that putative protein interaction sites in the p53 proline-rich domain are dispensable for tumor suppression. Mol Cell Biol. 2007 Feb;27(4):1425-32
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory