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Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(cre/ERT2)Tyj
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Tyler Jacks
MGI ID: MGI:3699244
Synonyms: Cre-ERT2, Gt(ROSA)26Sortm1(cre/ESR1)Tyj, R26-Cre-ERT2, Rosa26CreER
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Lower bone mass and reduced bone size in Gt(ROSA)26Sortm1(Pyy)Paba/Gt(ROSA)26Sortm1(cre/ERT2)Tyj females

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:118233
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
    A cassette containing Cre-ERT2 was inserted into the locus. (J:118233)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gt(ROSA)26Sor     Summary of all recombinase alleles driven by Gt(ROSA)26Sor. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  433 strains or lines available
References
Original:  J:118233 Ventura A, et al., Restoration of p53 function leads to tumour regression in vivo. Nature. 2007 Feb 8;445(7128):661-5
All:  193 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory