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Targeted Allele Detail
Symbol: Cd8atm1Welm
Name: CD8 antigen, alpha chain; targeted mutation 1, Wilfried Ellmeier
MGI ID: MGI:3698402
Synonyms: N2
Gene: Cd8a  Location: Chr6:71373427-71379173 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:113136
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of the enhancer 8ii, specifically cluster IV DNaseI hypersensitivity sites 4 and 5 referred to as C8ii (CIV-4,5), was deleted by homologous recombination in ES cells, leaving a neo selection cassette in place of the 8ii enhancer. (J:113136)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  20 strains or lines available
Original:  J:113136 Ellmeier W, et al., Combined deletion of CD8 locus cis-regulatory elements affects initiation but not maintenance of CD8 expression. Immunity. 2002 May;16(5):623-34
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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