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Surf1tm2.1Zev
Targeted Allele Detail
Nomenclature
Symbol: Surf1tm2.1Zev
Name: surfeit gene 1; targeted mutation 2.1, Massimo Zeviani
MGI ID: MGI:3698400
Synonyms: Surf1loxP
Gene: Surf1  Location: Chr2:26913381-26916530 bp, - strand  Genetic Position: Chr2, 19.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117871
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThis allele results after the cre mediated excision of the neomycin resistance cassette in Surf1tm2Zev. The loxP remaining in exon 7 disrupts the reading frame from nucleotide 674 downstream of the cDNA and the replacement of the codon encoding N225 with a TAA stop codon. This frame shift would putatively result in the elimination of 81 amino acids from the carboxy terminus, however, no protein was detected by Western blot. (J:117871)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Surf1 Mutation:  9 strains or lines available
References
Original:  J:117871 Dell'agnello C, et al., Increased longevity and refractoriness to Ca2+-dependent neurodegeneration in Surf1 knockout mice. Hum Mol Genet. 2007 Feb 15;16(4):431-44
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory