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Foxp3tm3(DTR/GFP)Ayr
Targeted Allele Detail
Nomenclature
Symbol: Foxp3tm3(DTR/GFP)Ayr
Name: forkhead box P3; targeted mutation 3, Alexander Y Rudensky
MGI ID: MGI:3698131
Synonyms: Foxp3DTR, Foxp3-DTR, Foxp3-GFP, Foxp3tm3Ayr
Gene: Foxp3  Location: ChrX:7579676-7595243 bp, + strand  Genetic Position: ChrX, 3.41 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117743
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Reporter)
Mutation:    Insertion
    A targeting vector was designed to insert an IRES-DTR-GFP with a floxed neo downstream of exon 11. (J:117743)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Foxp3 Mutation:  45 strains or lines available
References
Original:  J:117743 Kim JM, et al., Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol. 2007 Feb;8(2):191-7
All:  136 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory