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Park2tm1Ykt
Targeted Allele Detail
Nomenclature
Symbol: Park2tm1Ykt
Name: Parkinson disease (autosomal recessive, juvenile) 2, parkin; targeted mutation 1, Yasuko Kitao
MGI ID: MGI:3698054
Gene: Park2  Location: Chr17:10840384-12063361 bp, + strand  Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117737
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Park2 Mutation:  14 strains or lines available
References
Original:  J:117737 Kitao Y, et al., Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation. Hum Mol Genet. 2007 Jan 1;16(1):50-60
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory