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Lyve1tm1Lhua
Targeted Allele Detail
Summary
Symbol: Lyve1tm1Lhua
Name: lymphatic vessel endothelial hyaluronan receptor 1; targeted mutation 1, Jung S Huang
MGI ID: MGI:3697727
Synonyms: Crsbp-1-
Gene: Lyve1  Location: Chr7:110449814-110462160 bp, - strand  Genetic Position: Chr7, 57.89 cM, cytoband F2
Alliance: Lyve1tm1Lhua page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:117713
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to remove parts of exon 2, intron 2, exon 3 and intron 3 of the gene, and also to create a frame shift. The vector contained a floxed cassette containing a neomycin resistance gene and a testes specific angiotensin-converting enzyme promoter driving expression of cre recombinase. The floxed cassette was excised from the locus upon passage through the male germline. (J:117713)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lyve1 Mutation:  15 strains or lines available
References
Original:  J:117713 Huang SS, et al., CRSBP-1/LYVE-l-null mice exhibit identifiable morphological and functional alterations of lymphatic capillary vessels. FEBS Lett. 2006 Nov 13;580(26):6259-68
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory